CST6

GENE INFORMATION

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Gene name

CST6

Synonyms

Description

cystatin E/M (HGNC Symbol)

Entrez gene summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

65779312 - 65780976

Ensembl

ENSG00000175315 (version 73.37)

Entrez gene

1474

UniProt

Q15828 (UniProt - Evidence at protein level)

neXtProt

NX_Q15828

Antibodypedia

CST6 antibodies
 

PROTEIN VIEW

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CST6-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CST6-001 ENSP00000311313
ENST00000312134
Q15828
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