CHRNA7

GENE INFORMATION

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Gene name

CHRNA7

Synonyms

Description

Cholinergic receptor, nicotinic, alpha 7 (neuronal) (HGNC Symbol)

Entrez gene summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q13.3

Chromosome location (bp)

32322691 - 32464722

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175344 (version 75.37)

Entrez gene

89832

UniProt

P36544 (UniProt - Evidence at protein level)

neXtProt

NX_P36544

Antibodypedia

CHRNA7 antibodies
 

PROTEIN VIEW

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CHRNA7-001
 
CHRNA7-002
 
CHRNA7-003
 
CHRNA7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNA7-001 ENSP00000303727
ENST00000306901
P36544
Show all »
Show » Show » 502 56.4 Yes 4
CHRNA7-002 ENSP00000399087
ENST00000437966
H3BM15
Show all »
Show » Show » 102 11.5 Yes 0
CHRNA7-003 ENSP00000407546
ENST00000454250
P36544
Show all »
Show » Show » 531 59.2 Yes 4
CHRNA7-201 ENSP00000405989
ENST00000455693
P36544
Show all »
Show » Show » 321 35.5 No 4