CHRNA7

GENE INFORMATION

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Gene name

CHRNA7

Synonyms

Description

cholinergic receptor, nicotinic, alpha 7 (neuronal) (HGNC Symbol)

Entrez gene summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

15 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

32322691 - 32464722

Ensembl

ENSG00000175344 (version 73.37)

Entrez gene

1139

UniProt

P36544 (UniProt - Evidence at protein level)

neXtProt

NX_P36544

Antibodypedia

CHRNA7 antibodies
 

PROTEIN VIEW

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CHRNA7-001
 
CHRNA7-002
 
CHRNA7-003
 
CHRNA7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNA7-001 ENSP00000303727
ENST00000306901
P36544
Show all »
Show » Show » 502 56.4 Yes 4
CHRNA7-002 ENSP00000399087
ENST00000437966
H3BM15
Show all »
Show » 102 11.5 Yes 0
CHRNA7-003 ENSP00000407546
ENST00000454250
P36544
Show all »
Show » Show » 531 59.2 Yes 4
CHRNA7-201 ENSP00000405989
ENST00000455693
P36544
Show all »
Show » Show » 321 35.5 No 4