CLCF1

GENE INFORMATION

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Gene name

CLCF1 (HGNC Symbol)

Synonyms

BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6

Description

cardiotrophin-like cytokine factor 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Chromosome

11 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

67131639 - 67141648

Ensembl

ENSG00000175505 (version 73.37)

Entrez gene

23529

UniProt

Q9UBD9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBD9

Antibodypedia

CLCF1 antibodies
 

PROTEIN VIEW

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CLCF1-001
 
CLCF1-002
 
CLCF1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLCF1-001 ENSP00000434122
ENST00000533438
Q9UBD9
Show all »
Show » Show » 215 24.1 Yes 0
CLCF1-002 ENSP00000309338
ENST00000312438
Q9UBD9
Show all »
Show » Show » 225 25.2 Yes 0
CLCF1-003 ENSP00000432553
ENST00000528474
Q9UBD9
Show all »
Show » Show » 215 24.1 Yes 0