HOXD8

GENE INFORMATION

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Gene name

HOXD8 (HGNC Symbol)

Synonyms

HOX4, HOX4E

Description

homeobox D8 (HGNC Symbol)

Entrez gene summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Chromosome

2 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

176994422 - 176997423

Ensembl

ENSG00000175879 (version 73.37)

Entrez gene

3234

UniProt

P13378 (UniProt - Evidence at transcript level)

neXtProt

NX_P13378

Antibodypedia

HOXD8 antibodies
 

PROTEIN VIEW

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HOXD8-001
 
HOXD8-002
 
HOXD8-003
 
HOXD8-004
 
HOXD8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HOXD8-001 ENSP00000315949
ENST00000313173
P13378
Show all »
Show » Show » 290 31.9 No 0
HOXD8-002 ENSP00000406045
ENST00000429017
Show » 106 12.9 No 0
HOXD8-003 ENSP00000409026
ENST00000450510
P13378
Show all »
Show » Show » 289 31.8 No 0
HOXD8-004 ENSP00000448196
ENST00000548663
F8VSA3
Show all »
Show » 186 21.6 No 0
HOXD8-201 ENSP00000437431
ENST00000544999
P13378
Show all »
Show » Show » 289 31.8 No 0