A2M

GENERAL INFORMATION

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Gene name

A2M

Gene description

Alpha-2-macroglobulin

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Extracellular positivity, mainly in plasma.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Data reliability

Supportive based on 2 antibodies.
HPA002265 , CAB017621
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

A2M (HGNC Symbol)

Synonyms

CPAMD5, FWP007, S863-7

Description

Alpha-2-macroglobulin (HGNC Symbol)

Entrez gene summary

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

9067664 - 9116229

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175899 (version 78.38)

Entrez gene

2

UniProt

P01023 (UniProt - Evidence at protein level)

neXtProt

NX_P01023

Antibodypedia

A2M antibodies


PROTEIN BROWSER

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ENST00000318602
 
ENST00000404455
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

A2M-001 ENSP00000323929
ENST00000318602
P01023
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Show » Show » 1474 163.3 Yes 0
A2M-002 ENSP00000385710
ENST00000404455
F8W7L3
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Show » Show » 168 18.7 Yes 0