A2M

GENE INFORMATION

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Gene name

A2M (HGNC Symbol)

Synonyms

CPAMD5, FWP007, S863-7

Description

alpha-2-macroglobulin (HGNC Symbol)

Entrez gene summary

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

p13.31

Chromosome location (bp)

9220260 - 9268825

Ensembl

ENSG00000175899 (version 73.37)

Entrez gene

2

UniProt

P01023 (UniProt - Evidence at protein level)

neXtProt

NX_P01023

Antibodypedia

A2M antibodies
 

PROTEIN VIEW

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A2M-001
 
A2M-002
 
A2M-010
 
A2M-012
 
A2M-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

A2M-001 ENSP00000323929
ENST00000318602
P01023
Show all »
Show » Show » 1474 163.3 Yes 0
A2M-002 ENSP00000385710
ENST00000404455
F8W7L3
Show all »
Show » 168 18.7 Yes 0
A2M-010 ENSP00000438599
ENST00000546069
H0YFH1
Show all »
73 7.9 No 0
A2M-012 ENSP00000443302
ENST00000543436
Show » 200 21.8 No 0
A2M-013 ENSP00000445717
ENST00000539638
F5H1E8
Show all »
Show » 90 9.8 Yes 0