CLK2

GENERAL INFORMATION

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Gene name

CLK2

Gene description

CDC-like kinase 2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate nuclear positivity. Additional cytoplasmic staining was observed in a few tissues. Bile ducts, spleen and soft tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA055366
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CLK2 (HGNC Symbol)

Synonyms

clk2

Description

CDC-like kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

1

Cytoband

q22

Chromosome location (bp)

155262868 - 155278491

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176444 (version 78.38)

Entrez gene

1196

UniProt

P49760 (UniProt - Evidence at protein level)

neXtProt

NX_P49760

Antibodypedia

CLK2 antibodies


PROTEIN BROWSER

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ENST00000355560
 
ENST00000361168
 
ENST00000368361
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLK2-001 ENSP00000357345
ENST00000368361
P49760
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Show » Show » 499 60.1 No 0
CLK2-002 ENSP00000354856
ENST00000361168
P49760
Show all »
Show » Show » 498 60 No 0
CLK2-003 ENSP00000347759
ENST00000355560
B1AVT0
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Show » Show » 497 59.9 No 0