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NORMAL TISSUE

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Expression summary

Ubiquitous cytoplasmic expression.

Reliability (APE)

Medium

Antibodies in assay

HPA008322, HPA008323
 

Tissue presentation order  

Organ

Cell type

Alphabetical

 

Tissue

Antibody staining

Annotated expression

Central nervous system (Brain)
Cerebral cortex Neuronal cells
Cerebral cortex Glial cells
Hippocampus Neuronal cells
Hippocampus Glial cells
Lateral ventricle Neuronal cells
Lateral ventricle Glial cells
Cerebellum Purkinje cells
Cerebellum Cells in granular layer
Cerebellum Cells in molecular layer
Blood and immune system (Hematopoietic)
Bone marrow Hematopoietic cells
Lymph node Germinal center cells
Lymph node Non-germinal center cells
Tonsil Germinal center cells
Tonsil Non-germinal center cells
Tonsil Squamous epithelial cells
Spleen Cells in white pulp
Spleen Cells in red pulp
Liver and pancreas
Liver Hepatocytes
Liver Bile duct cells
Gall bladder Glandular cells
Pancreas Exocrine glandular cells
Pancreas Islets of Langerhans
Digestive tract (GI-tract)
Oral mucosa Squamous epithelial cells
Salivary gland Glandular cells
Esophagus Squamous epithelial cells
Stomach, upper Glandular cells
Stomach, lower Glandular cells
Duodenum Glandular cells
Small intestine Glandular cells
Appendix Glandular cells
Appendix Lymphoid tissue
Colon Glandular cells
Rectum Glandular cells
  
HPA008322
HPA008323
  

Tissue

Antibody staining

Annotated expression

Respiratory system (Lung)
Nasopharynx Respiratory epithelial cells
Bronchus Respiratory epithelial cells
Lung Pneumocytes
Lung Macrophages
Cardiovascular system (Heart and blood vessels)
Heart muscle Myocytes
Breast and female reproductive system (Female tissues)
Breast Glandular cells
Vagina Squamous epithelial cells
Cervix, uterine Squamous epithelial cells
Cervix, uterine Glandular cells
Uterus, pre-menopause Glandular cells
Uterus, pre-menopause Cells in endometrial stroma
Uterus, post-menopause Glandular cells
Uterus, post-menopause Cells in endometrial stroma
Fallopian tube Glandular cells
Ovary Follicle cells
Ovary Ovarian stroma cells
Placenta
Placenta Trophoblastic cells
Placenta Decidual cells
Male reproductive system (Male tissues)
Testis Cells in seminiferus ducts
Testis Leydig cells
Epididymis Glandular cells
Prostate Glandular cells
Seminal vesicle Glandular cells
Urinary tract (Kidney and bladder)
Kidney Cells in glomeruli
Kidney Cells in tubules
Urinary bladder Urothelial cells
Skin and soft tissues
Skin Epidermal cells
Vulva/anal skin Epidermal cells
Skeletal muscle Myocytes
Smooth muscle Smooth muscle cells
Endocrine glands
Thyroid gland Glandular cells
Parathyroid gland Glandular cells
Adrenal gland Glandular cells
  
HPA008322
HPA008323
 
 

Antibody HPA008322

 

Antibody HPA008323

 
 
Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.
 
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
 

Summary

Most normal tissues showed weak to moderate cytoplasmic staining. Kidney tubules and glandular cells in exocrine pancreas, small intestine and stomach were strongly stained. Cells of the CNS and lymphoid tissues were mainly negative.   Normal tissues generally showed moderate cytoplasmic positivity. Strong immunoreactivity was observed in several cell types including enteroendocrine cells, thyroid, trophoblasts and breast. Cilia were strongly stained.  

Validation

Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
 
Two (or more) antibodies yielding similar or partly similar staining patterns and there is no available gene/protein characterization data
 

Level of antibody staining





Strong
Moderate
Weak
Negative



Level of annotated protein expression





High
Medium
Low
None