PNMA1

GENE INFORMATION

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Gene name

PNMA1 (HGNC Symbol)

Synonyms

MA1

Description

paraneoplastic Ma antigen 1 (HGNC Symbol)

Entrez gene summary

The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies.[supplied by OMIM, May 2010]

Chromosome

14 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

74178494 - 74181128

Ensembl

ENSG00000176903 (version 73.37)

Entrez gene

9240

UniProt

Q8ND90 (UniProt - Evidence at protein level)

neXtProt

NX_Q8ND90

Antibodypedia

PNMA1 antibodies
 

PROTEIN VIEW

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PNMA1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PNMA1-001 ENSP00000318914
ENST00000316836
Q8ND90
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