FUT2

GENERAL INFORMATION

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Gene name

FUT2

Gene description

Fucosyltransferase 2 (secretor status included)

Protein class

Blood group antigen proteins
Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (duodenum)
GTEx:Tissue enhanced (salivary gland)

Protein evidence

Evidence at transcript level

Protein localization

Most normal tissues displayed moderate cytoplasmic staining. Strong immunoreactivity was observed in smooth muscle, exocrine pancreas and trophoblasts. Additional luminal membrane positivity was observed in the gastrointestinal tract. Squamous epithelia were in general weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA014402
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (duodenum)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (salivary gland)

Organ

Expression



GENE INFORMATION

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Gene name

FUT2 (HGNC Symbol)

Synonyms

SE, Se2, SEC2, sej

Description

Fucosyltransferase 2 (secretor status included) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

48695971 - 48705950

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000176920 (version 78.38)

Entrez gene

2524

UniProt

Q10981 (UniProt - Evidence at transcript level)

neXtProt

NX_Q10981

Antibodypedia

FUT2 antibodies


PROTEIN BROWSER

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ENST00000391876
 
ENST00000425340
 
ENST00000522966
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FUT2-001 ENSP00000387498
ENST00000425340
Q10981
Show all »
Show » Show » 343 39 No 2
FUT2-002 ENSP00000430227
ENST00000522966
E7EW73
Show all »
Show » Show » 220 25.4 No 1
FUT2-201 ENSP00000375748
ENST00000391876
Q10981
Show all »
Show » Show » 343 39 No 2