SCN4B

GENE INFORMATION

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Gene name

SCN4B (HGNC Symbol)

Synonyms

LQT10

Description

sodium channel, voltage-gated, type IV, beta subunit (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

118004092 - 118023603

Ensembl

ENSG00000177098 (version 73.37)

Entrez gene

6330

UniProt

Q8IWT1 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IWT1

Antibodypedia

SCN4B antibodies
 

PROTEIN VIEW

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SCN4B-001
 
SCN4B-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCN4B-001 ENSP00000322460
ENST00000324727
Q8IWT1
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Show » Show » 228 25 Yes 1
SCN4B-004 ENSP00000436343
ENST00000529878
Q8IWT1
Show all »
Show » Show » 94 9.9 No 1