KCNA3

GENE INFORMATION

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Gene name

KCNA3 (HGNC Symbol)

Synonyms

HLK3, HPCN3, Kv1.3, MK3

Description

potassium voltage-gated channel, shaker-related subfamily, member 3 (HGNC Symbol)

Entrez gene summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

111214310 - 111217655

Ensembl

ENSG00000177272 (version 73.37)

Entrez gene

3738

UniProt

P22001 (UniProt - Evidence at transcript level)

neXtProt

NX_P22001

Antibodypedia

KCNA3 antibodies
 

PROTEIN VIEW

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KCNA3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNA3-001 ENSP00000358784
ENST00000369769
P22001
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