KCNA2

GENE INFORMATION

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Gene name

KCNA2 (HGNC Symbol)

Synonyms

HK4, Kv1.2

Description

potassium voltage-gated channel, shaker-related subfamily, member 2 (HGNC Symbol)

Entrez gene summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

111136202 - 111174096

Ensembl

ENSG00000177301 (version 73.37)

Entrez gene

3737

UniProt

P16389 (UniProt - Evidence at protein level)

neXtProt

NX_P16389

Antibodypedia

KCNA2 antibodies
 

PROTEIN VIEW

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KCNA2-001
 
KCNA2-002
 
KCNA2-003
 
KCNA2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNA2-001 ENSP00000358785
ENST00000369770
P16389
Show all »
Show » Show » 356 41 No 3
KCNA2-002 ENSP00000433109
ENST00000485317
P16389
Show all »
Show » Show » 499 56.7 No 6
KCNA2-003 ENSP00000314520
ENST00000316361
P16389
Show all »
Show » Show » 499 56.7 No 6
KCNA2-201 ENSP00000415257
ENST00000440270
P16389
Show all »
Show » Show » 499 56.7 No 6