TGIF1

GENE INFORMATION

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Gene name

TGIF1 (HGNC Symbol)

Synonyms

HPE4, TGIF

Description

TGFB-induced factor homeobox 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

Chromosome

18

Cytoband

p11.31

Chromosome location (bp)

3411608 - 3459978

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177426 (version 78.38)

Entrez gene

7050

UniProt

Q15583 (UniProt - Evidence at protein level)

neXtProt

NX_Q15583

Antibodypedia

TGIF1 antibodies
 

PROTEIN VIEW

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TGIF1-001
 
TGIF1-002
 
TGIF1-003
 
TGIF1-004
 
TGIF1-005
 
TGIF1-006
 
TGIF1-007
 
TGIF1-008
 
TGIF1-010
 
TGIF1-011
 
TGIF1-012
 
TGIF1-015
 
TGIF1-016
 
TGIF1-017
 
TGIF1-018
 
TGIF1-019
 
TGIF1-020
 
TGIF1-201
 
TGIF1-202
 
TGIF1-203
 
TGIF1-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TGIF1-001 ENSP00000483499
ENST00000618001
Q15583
Show all »
Show » Show » 286 31.1 No 0
TGIF1-002 ENSP00000339631
ENST00000343820
Q15583
Show all »
Show » Show » 272 29.7 No 0
TGIF1-003 ENSP00000327959
ENST00000330513
Q15583
Show all »
Show » Show » 401 43 No 0
TGIF1-004 ENSP00000449501
ENST00000472042
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-005 ENSP00000448934
ENST00000546979
F8VYL4
Show all »
Show » Show » 118 13.4 No 0
TGIF1-006 ENSP00000384133
ENST00000407501
Q15583
Show all »
Show » Show » 272 29.7 No 0
TGIF1-007 ENSP00000446944
ENST00000551402
F8W1J9
Show all »
Show » Show » 132 15 No 0
TGIF1-008 ENSP00000449287
ENST00000552383
F8VWK5
Show all »
Show » Show » 168 18.7 No 0
TGIF1-010 ENSP00000449531
ENST00000550958
F8VW34
Show all »
Show » Show » 131 14.9 No 0
TGIF1-011 ENSP00000448121
ENST00000549780
F8VUY0
Show all »
Show » Show » 219 24.1 No 0
TGIF1-012 ENSP00000449973
ENST00000549253
F8VXG3
Show all »
Show » Show » 92 10.8 No 0
TGIF1-015 ENSP00000450025
ENST00000551541
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-016 ENSP00000343969
ENST00000345133
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-017 ENSP00000449580
ENST00000549546
F8VVS9
Show all »
Show » Show » 246 27.1 No 0
TGIF1-018 ENSP00000449722
ENST00000549468
F8VX54
Show all »
Show » Show » 133 15.1 No 0
TGIF1-019 ENSP00000446838
ENST00000551333
F8VZH2
Show all »
Show » Show » 138 15.6 No 0
TGIF1-020 ENSP00000462285
ENST00000577543
J3KS32
Show all »
Show » Show » 84 9.4 No 0
TGIF1-201 ENSP00000383031
ENST00000400167
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-202 ENSP00000385206
ENST00000401449
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-203 ENSP00000384970
ENST00000405385
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-204 ENSP00000447747
ENST00000548489
Q15583
Show all »
Show » Show » 252 27.7 No 0