TGIF1

GENERAL INFORMATION

? »

Gene name

TGIF1

Gene description

TGFB-induced factor homeobox 1

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

21
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

? »

Data reliability

Pending normal tissue annotation.
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

? »
Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

? »

Gene name

TGIF1 (HGNC Symbol)

Synonyms

HPE4, TGIF

Description

TGFB-induced factor homeobox 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

Chromosome

18

Cytoband

p11.31

Chromosome location (bp)

3411608 - 3459978

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177426 (version 78.38)

Entrez gene

7050

UniProt

Q15583 (UniProt - Evidence at protein level)

neXtProt

NX_Q15583

Antibodypedia

TGIF1 antibodies


PROTEIN BROWSER

? »
 
 
 « 
 
ENST00000330513
 
ENST00000343820
 
ENST00000345133
 
ENST00000400167
 
ENST00000401449
 
ENST00000405385
 
ENST00000407501
 
ENST00000472042
 
ENST00000546979
 
ENST00000548489
 
ENST00000549253
 
ENST00000549468
 
ENST00000549546
 
ENST00000549780
 
ENST00000550958
 
ENST00000551333
 
ENST00000551402
 
ENST00000551541
 
ENST00000552383
 
ENST00000577543
 
ENST00000618001
 
 » 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TGIF1-001 ENSP00000483499
ENST00000618001
Q15583
Show all »
Show » Show » 286 31.1 No 0
TGIF1-002 ENSP00000339631
ENST00000343820
Q15583
Show all »
Show » Show » 272 29.7 No 0
TGIF1-003 ENSP00000327959
ENST00000330513
Q15583
Show all »
Show » Show » 401 43 No 0
TGIF1-004 ENSP00000449501
ENST00000472042
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-005 ENSP00000448934
ENST00000546979
F8VYL4
Show all »
Show » Show » 118 13.4 No 0
TGIF1-006 ENSP00000384133
ENST00000407501
Q15583
Show all »
Show » Show » 272 29.7 No 0
TGIF1-007 ENSP00000446944
ENST00000551402
F8W1J9
Show all »
Show » Show » 132 15 No 0
TGIF1-008 ENSP00000449287
ENST00000552383
F8VWK5
Show all »
Show » Show » 168 18.7 No 0
TGIF1-010 ENSP00000449531
ENST00000550958
F8VW34
Show all »
Show » Show » 131 14.9 No 0
TGIF1-011 ENSP00000448121
ENST00000549780
F8VUY0
Show all »
Show » Show » 219 24.1 No 0
TGIF1-012 ENSP00000449973
ENST00000549253
F8VXG3
Show all »
Show » Show » 92 10.8 No 0
TGIF1-015 ENSP00000450025
ENST00000551541
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-016 ENSP00000343969
ENST00000345133
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-017 ENSP00000449580
ENST00000549546
F8VVS9
Show all »
Show » Show » 246 27.1 No 0
TGIF1-018 ENSP00000449722
ENST00000549468
F8VX54
Show all »
Show » Show » 133 15.1 No 0
TGIF1-019 ENSP00000446838
ENST00000551333
F8VZH2
Show all »
Show » Show » 138 15.6 No 0
TGIF1-020 ENSP00000462285
ENST00000577543
J3KS32
Show all »
Show » Show » 84 9.4 No 0
TGIF1-201 ENSP00000383031
ENST00000400167
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-202 ENSP00000385206
ENST00000401449
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-203 ENSP00000384970
ENST00000405385
Q15583
Show all »
Show » Show » 252 27.7 No 0
TGIF1-204 ENSP00000447747
ENST00000548489
Q15583
Show all »
Show » Show » 252 27.7 No 0