GRB2

GENE INFORMATION

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Gene name

GRB2 (HGNC Symbol)

Synonyms

NCKAP2

Description

growth factor receptor-bound protein 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q25.1

Chromosome location (bp)

73314157 - 73401790

Ensembl

ENSG00000177885 (version 73.37)

Entrez gene

2885

UniProt

P62993 (UniProt - Evidence at protein level)

neXtProt

NX_P62993

Antibodypedia

GRB2 antibodies
 

PROTEIN VIEW

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GRB2-001
 
GRB2-002
 
GRB2-003
 
GRB2-004
 
GRB2-007
 
GRB2-008
 
GRB2-009
 
GRB2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRB2-001 ENSP00000339007
ENST00000316804
P62993
Show all »
Show » Show » 217 25.2 No 0
GRB2-002 ENSP00000376345
ENST00000392562
P62993
Show all »
Show » Show » 217 25.2 No 0
GRB2-003 ENSP00000376347
ENST00000392564
P62993
Show all »
Show » Show » 217 25.2 No 0
GRB2-004 ENSP00000376346
ENST00000392563
P62993
Show all »
Show » Show » 176 20.6 No 0
GRB2-007 ENSP00000462785
ENST00000582582
J3KT38
Show all »
Show » Show » 111 12.8 No 0
GRB2-008 ENSP00000464279
ENST00000578961
J3QRL5
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Show » Show » 156 17.6 No 0
GRB2-009 ENSP00000463525
ENST00000581959
42 4.7 No 0
GRB2-201 ENSP00000317360
ENST00000316615
P62993
Show all »
Show » Show » 176 20.6 No 0