ERBB4

GENE INFORMATION

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Gene name

ERBB4

Synonyms

Description

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q34

Chromosome location (bp)

212240446 - 213403565

Ensembl

ENSG00000178568 (version 73.37)

Entrez gene

2066

UniProt

Q15303 (UniProt - Evidence at protein level)

neXtProt

NX_Q15303

Antibodypedia

ERBB4 antibodies
 

PROTEIN VIEW

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ERBB4-001
 
ERBB4-002
 
ERBB4-004
 
ERBB4-005
 
ERBB4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERBB4-001 ENSP00000342235
ENST00000342788
Q15303
Show all »
Show » Show » 1308 146.8 Yes 1
ERBB4-002 ENSP00000403204
ENST00000436443
Q15303
Show all »
Show » Show » 1292 145.2 Yes 1
ERBB4-004 ENSP00000260943
ENST00000260943
E9PDR1
Show all »
Show » Show » 731 80.9 Yes 1
ERBB4-005 ENSP00000405564
ENST00000435846
E9PDR1
Show all »
Show » 128 14.6 No 0
ERBB4-201 ENSP00000385565
ENST00000402597
Q15303
Show all »
Show » Show » 1298 145.6 Yes 1