CALR

GENE INFORMATION

? »

Gene name

CALR (HGNC Symbol)

Synonyms

cC1qR, CRT, FLJ26680, RO, SSA

Description

calreticulin (HGNC Symbol)

Entrez gene summary

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

13049392 - 13055303

Ensembl

ENSG00000179218 (version 73.37)

Entrez gene

811

UniProt

P27797 (UniProt - Evidence at protein level)

neXtProt

NX_P27797

Antibodypedia

CALR antibodies
 

PROTEIN VIEW

? »
 
 
 
CALR-001
 
CALR-006
 
CALR-007
 
CALR-008
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CALR-001 ENSP00000320866
ENST00000316448
P27797
Show all »
Show » Show » 417 48.1 Yes 0
CALR-006 ENSP00000465918
ENST00000586760
Show » 163 19 No 0
CALR-007 ENSP00000466037
ENST00000586967
13 1.3 No 0
CALR-008 ENSP00000465105
ENST00000588454
K7EJB9
Show all »
Show » Show » 247 28.4 Yes 0