PTPN11

GENE INFORMATION

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Gene name

PTPN11 (HGNC Symbol)

Synonyms

BPTP3, NS1, PTP2C, SH-PTP2, SHP-2, SHP2

Description

protein tyrosine phosphatase, non-receptor type 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

12 (Chromosome progress)

Cytoband

q24.13

Chromosome location (bp)

112856155 - 112947717

Ensembl

ENSG00000179295 (version 73.37)

Entrez gene

5781

UniProt

Q06124 (UniProt - Evidence at protein level)

neXtProt

NX_Q06124

Antibodypedia

PTPN11 antibodies
 

PROTEIN VIEW

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PTPN11-001
 
PTPN11-002
 
PTPN11-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN11-001 ENSP00000340944
ENST00000351677
Q06124
Show all »
Show » Show » 593 68 No 0
PTPN11-002 ENSP00000376376
ENST00000392597
Q06124
Show all »
Show » Show » 460 52.8 No 0
PTPN11-004 ENSP00000437013
ENST00000530818
Show » Show » 108 12.2 No 0