The gene information section lists the gene name (HUGO Gene Nomenclature Committee (HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
Gene name
HLA-DQB1 (HGNC Symbol)
Synonyms
CELIAC1, HLA-DQB, IDDM1
Description
major histocompatibility complex, class II, DQ beta 1 (HGNC Symbol)
Entrez gene summary
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
Q5Y7D6 [Target identity:100%; Query identity:100%] HLA class II histocompatibility antigen, DQ beta 1 chain; MHC class II antigen; cDNA, FLJ79232, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain Q67AI9 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AJ0 [Target identity:89%; Query identity:100%] MHC class II antigen F8LFZ1 [Target identity:70%; Query identity:100%] MHC class II antigen F8LFZ3 [Target identity:70%; Query identity:100%] MHC class II antigen O19741 [Target identity:36%; Query identity:100%] HLA-DRB3 protein O78224 [Target identity:21%; Query identity:100%] Lymphocyte antigen Q4VC55 [Target identity:13%; Query identity:100%] MHC class II antigen Q5BLN2 [Target identity:13%; Query identity:100%] MHC class II antigen Q5BLN3 [Target identity:13%; Query identity:100%] MHC class II antigen Q8MHQ2 [Target identity:12%; Query identity:100%] MHC class II antigen Q8SNB9 [Target identity:12%; Query identity:100%] MHC class II antigen Q9BCT8 [Target identity:12%; Query identity:100%] MHC class II HLA-DQ-beta
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0006955 [immune response] GO:0016021 [integral to membrane] GO:0042613 [MHC class II protein complex]
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0006955 [immune response] GO:0016021 [integral to membrane] GO:0042613 [MHC class II protein complex]
Q5Y7D6 [Target identity:100%; Query identity:100%] HLA class II histocompatibility antigen, DQ beta 1 chain; MHC class II antigen; cDNA, FLJ79232, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain Q67AI9 [Target identity:89%; Query identity:100%] MHC class II antigen Q67AJ0 [Target identity:89%; Query identity:100%] MHC class II antigen F8LFZ1 [Target identity:70%; Query identity:100%] MHC class II antigen F8LFZ3 [Target identity:70%; Query identity:100%] MHC class II antigen O19741 [Target identity:36%; Query identity:100%] HLA-DRB3 protein O78224 [Target identity:21%; Query identity:100%] Lymphocyte antigen Q4VC55 [Target identity:13%; Query identity:100%] MHC class II antigen Q5BLN2 [Target identity:13%; Query identity:100%] MHC class II antigen Q5BLN3 [Target identity:13%; Query identity:100%] MHC class II antigen Q8MHQ2 [Target identity:12%; Query identity:100%] MHC class II antigen Q8SNB9 [Target identity:12%; Query identity:100%] MHC class II antigen Q9BCT8 [Target identity:12%; Query identity:100%] MHC class II HLA-DQ-beta
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0006955 [immune response] GO:0016021 [integral to membrane] GO:0042613 [MHC class II protein complex]
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0006955 [immune response] GO:0016021 [integral to membrane] GO:0042613 [MHC class II protein complex]
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0006955 [immune response] GO:0016021 [integral to membrane] GO:0042613 [MHC class II protein complex]
A2AAY8 [Target identity:100%; Query identity:100%] HLA class II histocompatibility antigen, DQ beta 1 chain Q4VC55 [Target identity:26%; Query identity:100%] MHC class II antigen Q5BLN2 [Target identity:26%; Query identity:100%] MHC class II antigen Q5BLN3 [Target identity:26%; Query identity:100%] MHC class II antigen Q8MHQ2 [Target identity:23%; Query identity:100%] MHC class II antigen Q8SNB9 [Target identity:23%; Query identity:100%] MHC class II antigen Q9BCT8 [Target identity:23%; Query identity:100%] MHC class II HLA-DQ-beta
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0006955 [immune response] GO:0016021 [integral to membrane] GO:0042613 [MHC class II protein complex]