The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
A majority of malignant cells showed moderate cytoplasmic staining with a granular pattern, often accompanied with nuclear staining in a fraction of the cells. Several prostate cancers were strongly stained, while most testicular, urothelial, renal and hepatocellular carcinomas were weakly stained or negative.
Mucinous ovarian cancers and fractions of cells in cases of colorectal cancers displayed strong staining. A majority of testicular cancers as well as a few breast, prostate, skin and urothelial cancers displayed moderate cytoplasmic positivity. Subsets of cells in malignant gliomas showed moderate nuclear staining. Malignant cells in general showed weak staining or were negative.
Validation
Two (or more) antibodies yielding dissimilar or partly similar staining patterns and there is no available gene/protein characterization data or only limited gene/protein characterization data
Two (or more) antibodies yielding dissimilar or partly similar staining patterns and there is no available gene/protein characterization data or only limited gene/protein characterization data
