CDH5

GENERAL INFORMATION

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Gene name

CDH5

Gene description

Cadherin 5, type 2 (vascular endothelium)

Protein class

Cancer-related genes
CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 2 antibodies.
HPA030562 , CAB028366
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CDH5 (HGNC Symbol)

Synonyms

7B4, CD144

Description

Cadherin 5, type 2 (vascular endothelium) (HGNC Symbol)

Entrez gene summary

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q21

Chromosome location (bp)

66366622 - 66404786

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179776 (version 78.38)

Entrez gene

1003

UniProt

P33151 (UniProt - Evidence at protein level)

neXtProt

NX_P33151

Antibodypedia

CDH5 antibodies


PROTEIN BROWSER

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ENST00000341529
 
ENST00000539168
 
ENST00000562048
 
ENST00000563425
 
ENST00000568023
 
ENST00000568155
 
ENST00000614547
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH5-001 ENSP00000344115
ENST00000341529
P33151
Show all »
Show » Show » 784 87.5 Yes 1
CDH5-002 ENSP00000461880
ENST00000539168
B4DTR2
Show all »
Show » Show » 223 24.3 No 1
CDH5-003 ENSP00000455655
ENST00000568023
Show » 17 1.8 No 0
CDH5-004 ENSP00000456093
ENST00000568155
H3BR64
Show all »
Show » 76 8.4 Yes 0
CDH5-005 ENSP00000455302
ENST00000562048
H3BPG1
Show all »
Show » Show » 131 14.6 Yes 0
CDH5-007 ENSP00000458878
ENST00000563425
I3L1J2
Show all »
Show » Show » 406 45.4 Yes 0
CDH5-201 ENSP00000479381
ENST00000614547
P33151
Show all »
Show » Show » 669 74.5 Yes 1