CCR8

GENE INFORMATION

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Gene name

CCR8 (HGNC Symbol)

Synonyms

CDw198, CKR-L1, CMKBR8, CMKBRL2, CY6, GPR-CY6, TER1

Description

chemokine (C-C motif) receptor 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p22.2

Chromosome location (bp)

39371197 - 39375171

Ensembl

ENSG00000179934 (version 73.37)

Entrez gene

1237

UniProt

P51685 (UniProt - Evidence at protein level)

neXtProt

NX_P51685

Antibodypedia

CCR8 antibodies
 

PROTEIN VIEW

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CCR8-001
 
CCR8-002
 
CCR8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR8-001 ENSP00000326432
ENST00000326306
P51685
Show all »
Show » Show » 355 40.8 No 7
CCR8-002 ENSP00000390104
ENST00000414803
C9JIP9
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Show » 118 13 No 0
CCR8-201 ENSP00000440474
ENST00000545843
Q3KNR3
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Show » Show » 272 31.6 No 5