SOCS4

GENERAL INFORMATION

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Gene name

SOCS4

Gene description

Suppressor of cytokine signaling 4

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic positivity. Occasionally additional membranous staining was observed, for example in gastrointestinal tract. Lymphoid tissues displayed strong immunoreactivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB013478
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SOCS4 (HGNC Symbol)

Synonyms

SOCS7

Description

Suppressor of cytokine signaling 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q22.3

Chromosome location (bp)

55027230 - 55049488

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180008 (version 78.38)

Entrez gene

122809

UniProt

Q8WXH5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WXH5

Antibodypedia

SOCS4 antibodies


PROTEIN BROWSER

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ENST00000339298
 
ENST00000395472
 
ENST00000555846
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOCS4-001 ENSP00000378855
ENST00000395472
Q8WXH5
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Show » Show » 440 50.6 No 0
SOCS4-002 ENSP00000452522
ENST00000555846
Q8WXH5
Show all »
Show » Show » 440 50.6 No 0
SOCS4-003 ENSP00000341327
ENST00000339298
Q8WXH5
Show all »
Show » Show » 440 50.6 No 0