F2

GENE INFORMATION

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Gene name

F2

Synonyms

Description

Coagulation factor II (thrombin) (HGNC Symbol)

Entrez gene summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

46740730 - 46761056

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180210 (version 75.37)

Entrez gene

2147

UniProt

P00734 (UniProt - Evidence at protein level)

neXtProt

NX_P00734

Antibodypedia

F2 antibodies
 

PROTEIN VIEW

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F2-001
 
F2-003
 
F2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F2-001 ENSP00000308541
ENST00000311907
P00734
Show all »
Show » Show » 622 70 Yes 0
F2-003 ENSP00000387413
ENST00000442468
C9JV37
Show all »
Show » Show » 324 35.9 No 0
F2-005 ENSP00000433907
ENST00000530231
E9PIT3
Show all »
Show » Show » 583 65.4 Yes 0