HIST1H2AC

GENERAL INFORMATION

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Gene name

HIST1H2AC

Gene description

Histone cluster 1, H2ac

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Data reliability

Supportive based on 1 antibody.
HPA041189
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HIST1H2AC (HGNC Symbol)

Synonyms

H2AFL

Description

Histone cluster 1, H2ac (HGNC Symbol)

Entrez gene summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p22.2

Chromosome location (bp)

26124145 - 26139116

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180573 (version 78.38)

Entrez gene

8334

UniProt

Q93077 (UniProt - Evidence at protein level)

neXtProt

NX_Q93077

Antibodypedia

HIST1H2AC antibodies


PROTEIN BROWSER

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ENST00000377791
 
ENST00000602637
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIST1H2AC-002 ENSP00000473534
ENST00000602637
Q93077
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Show » Show » 130 14.1 No 0
HIST1H2AC-201 ENSP00000367022
ENST00000377791
Q93077
Show all »
Show » Show » 130 14.1 No 0