CXCR2

GENE INFORMATION

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Gene name

CXCR2 (HGNC Symbol)

Synonyms

CD182, CMKAR2, IL8RB

Description

chemokine (C-X-C motif) receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Chromosome

2 (Chromosome progress)

Cytoband

q35

Chromosome location (bp)

218990012 - 219001976

Ensembl

ENSG00000180871 (version 73.37)

Entrez gene

3579

UniProt

P25025 (UniProt - Evidence at protein level)

neXtProt

NX_P25025

Antibodypedia

CXCR2 antibodies
 

PROTEIN VIEW

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CXCR2-001
 
CXCR2-002
 
CXCR2-003
 
CXCR2-004
 
CXCR2-005
 
CXCR2-006
 
CXCR2-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CXCR2-001 ENSP00000319635
ENST00000318507
P25025
Show all »
Show » Show » 360 40.8 No 7
CXCR2-002 ENSP00000413686
ENST00000453237
C9JW47
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Show » Show » 201 22.7 No 4
CXCR2-003 ENSP00000410506
ENST00000449014
15 1.9 No 0
CXCR2-004 ENSP00000415148
ENST00000454148
C9JG19
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Show » Show » 136 15.3 No 3
CXCR2-005 ENSP00000392698
ENST00000428565
C9J1J7
Show all »
Show » Show » 172 19.5 No 3
CXCR2-006 ENSP00000416815
ENST00000418878
15 1.9 No 0
CXCR2-007 ENSP00000392348
ENST00000415392
C9J2F9
Show all »
Show » Show » 138 15.5 No 3