The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Malignant cells showed moderate cytoplasmic and occasional membranous positivity. Several cases of ovarian cancers showed strong immunoreactivity. Most cases of gliomas, testicular and renal cancers were negative or weakly stained.
Cancer tissues showed moderate to strong cytoplasmic staining with additional membranous positivity in several cases. Several cases of malignant gliomas, lymphomas and liver cancers were negative.
Ovarian, cervical and endometrial cancers along with a few cases of breast, thyroid, urothelial, gastric and pancreatic cancers showed strong cytoplasmic and occasional membranous staining. Remaining cancer tissues were negative.
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
The multi-targeting antibody yielding a staining pattern partly consistent with limited gene/protein characterization data or there is no available gene/protein characterization data for all or at least one of the genes
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data