PENK

GENERAL INFORMATION

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Gene name

PENK

Gene description

Proenkephalin

Protein class

Plasma proteins
Predicted secreted proteins
Transporters

Predicted localization

Secreted

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (adrenal gland, testis)
GTEx:Tissue enhanced (adrenal gland, testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 2 antibodies.
HPA013138 , CAB016390
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (adrenal gland, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adrenal gland, testis)

Organ

Expression



GENE INFORMATION

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Gene name

PENK

Synonyms

Description

Proenkephalin (HGNC Symbol)

Entrez gene summary

Chromosome

8

Cytoband

q12.1

Chromosome location (bp)

56436674 - 56446734

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181195 (version 78.38)

Entrez gene

5179

UniProt

P01210 (UniProt - Evidence at protein level)

neXtProt

NX_P01210

Antibodypedia

PENK antibodies


PROTEIN BROWSER

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ENST00000314922
 
ENST00000451791
 
ENST00000517415
 
ENST00000518770
 
ENST00000518974
 
ENST00000523051
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PENK-001 ENSP00000400894
ENST00000451791
P01210
Show all »
Show » Show » 267 30.8 Yes 0
PENK-002 ENSP00000324248
ENST00000314922
P01210
Show all »
Show » Show » 267 30.8 Yes 0
PENK-003 ENSP00000430592
ENST00000518770
E5RJ72
Show all »
Show » Show » 92 10.3 Yes 0
PENK-005 ENSP00000429326
ENST00000523051
E5RIP6
Show all »
Show » Show » 79 8.8 Yes 0
PENK-007 ENSP00000430268
ENST00000517415
H0YBT5
Show all »
Show » Show » 88 10 Yes 0
PENK-010 ENSP00000428012
ENST00000518974
E5RFR1
Show all »
Show » Show » 105 11.8 Yes 0