The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Moderate cytoplasmic staining was seen in most normal tissues. Parietal cells in gastric mucosa, paneth cells in the intestine, glandular cells in epididymis and proximal tubules in kidney were strongly positive. A few tissues showed additional rare nuclear staining. Liver was negative.
Most normal tissues displayed moderate cytoplasmic and nuclear positivity. Strong cytoplasmic staining was seen in intestinal glands, exocrine pancreas, trophoblastic cells, epididymis, Purkinje cells, bone marrow and a subset of non-germinal center cells.
A majority of normal tissues showed weak to moderate nuclear positivity. Strong nuclear positivity was observed in trophoblastic cells, thyroid and parathyroid glands while hepatocytes and proximal tubule displayed strong cytoplasmic immunoreactivity.
Cells in CNS and myocytes were negative or weakly staiend.
Normal cells displayed moderate to strong nuclear and cytoplasmic immunoreactivity. The normal liver was weakly stained.