EDDM3A

GENERAL INFORMATION

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Gene name

EDDM3A

Gene description

Epididymal protein 3A

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (kidney, testis)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in testis and epididymis.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA049952
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (kidney, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

EDDM3A (HGNC Symbol)

Synonyms

FAM12A, HE3-ALPHA

Description

Epididymal protein 3A (HGNC Symbol)

Entrez gene summary

Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

20731699 - 20748380

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181562 (version 78.38)

Entrez gene

10876

UniProt

Q14507 (UniProt - Evidence at transcript level)

neXtProt

NX_Q14507

Antibodypedia

EDDM3A antibodies


PROTEIN BROWSER

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ENST00000326842
 
ENST00000618864
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EDDM3A-001 ENSP00000315098
ENST00000326842
Q14507
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Show » Show » 147 17.6 Yes 0
EDDM3A-201 ENSP00000479026
ENST00000618864
Show » 147 17.5 Yes 0