BAI1

GENE INFORMATION

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Gene name

BAI1

Synonyms

Description

brain-specific angiogenesis inhibitor 1 (HGNC Symbol)

Entrez gene summary

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

143530791 - 143626370

Ensembl

ENSG00000181790 (version 73.37)

Entrez gene

575

UniProt

O14514 (UniProt - Evidence at protein level)

neXtProt

NX_O14514

Antibodypedia

BAI1 antibodies
 

PROTEIN VIEW

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BAI1-001
 
BAI1-004
 
BAI1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BAI1-001 ENSP00000430945
ENST00000517894
O14514
Show all »
Show » Show » 1584 173.5 Yes 7
BAI1-004 ENSP00000427783
ENST00000521208
E5RG74
Show all »
Show » Show » 1159 126.7 Yes 5
BAI1-201 ENSP00000313046
ENST00000323289
O14514
Show all »
Show » Show » 1584 173.5 Yes 7