CLDN7

GENE INFORMATION

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Gene name

CLDN7 (HGNC Symbol)

Synonyms

CEPTRL2, CPETRL2, Hs.84359

Description

claudin 7 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Chromosome

17 (Chromosome progress)

Cytoband

p13.1

Chromosome location (bp)

7163222 - 7167302

Ensembl

ENSG00000181885 (version 73.37)

Entrez gene

1366

UniProt

O95471 (UniProt - Evidence at protein level)

neXtProt

NX_O95471

Antibodypedia

CLDN7 antibodies
 

PROTEIN VIEW

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CLDN7-001
 
CLDN7-003
 
CLDN7-004
 
CLDN7-006
 
CLDN7-007
 
CLDN7-008
 
CLDN7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN7-001 ENSP00000353475
ENST00000360325
O95471
Show all »
Show » Show » 211 22.4 Yes 3
CLDN7-003 ENSP00000396638
ENST00000397317
O95471
Show all »
Show » Show » 211 22.4 Yes 3
CLDN7-004 ENSP00000467220
ENST00000571932
K7EP40
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Show » Show » 129 13.6 Yes 1
CLDN7-006 ENSP00000460796
ENST00000575313
I3L3X1
Show all »
Show » Show » 194 20.7 No 3
CLDN7-007 ENSP00000460550
ENST00000574070
I3L3L6
Show all »
Show » Show » 100 10.5 Yes 2
CLDN7-008 ENSP00000465963
ENST00000571881
K7EL87
Show all »
Show » Show » 140 15.1 Yes 0
CLDN7-201 ENSP00000445131
ENST00000538261
F5H496
Show all »
Show » Show » 145 15.2 Yes 2