IDH2

GENE INFORMATION

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Gene name

IDH2

Synonyms

Description

isocitrate dehydrogenase 2 (NADP+), mitochondrial (HGNC Symbol)

Entrez gene summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q26.1

Chromosome location (bp)

90626277 - 90645736

Ensembl

ENSG00000182054 (version 73.37)

Entrez gene

3418

UniProt

P48735 (UniProt - Evidence at protein level)

neXtProt

NX_P48735

Antibodypedia

IDH2 antibodies
 

PROTEIN VIEW

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IDH2-001
 
IDH2-002
 
IDH2-003
 
IDH2-004
 
IDH2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDH2-001 ENSP00000331897
ENST00000330062
P48735
Show all »
Show » Show » 452 50.9 No 0
IDH2-002 ENSP00000453016
ENST00000559482
H0YL11
Show all »
Show » 312 35.3 No 0
IDH2-003 ENSP00000453254
ENST00000560061
H0YLL5
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Show » 38 4.1 No 0
IDH2-004 ENSP00000446147
ENST00000540499
B4DFL2
Show all »
Show » 400 45.2 No 0
IDH2-201 ENSP00000438457
ENST00000539790
B4DSZ6
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Show » 322 36.2 No 0