BACE2

GENE INFORMATION

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Gene name

BACE2 (HGNC Symbol)

Synonyms

AEPLC, ALP56, CEAP1, DRAP

Description

beta-site APP-cleaving enzyme 2 (HGNC Symbol)

Entrez gene summary

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

21 (Chromosome progress)

Cytoband

q22.2

Chromosome location (bp)

42539728 - 42648524

Ensembl

ENSG00000182240 (version 73.37)

Entrez gene

25825

UniProt

Q9Y5Z0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5Z0

Antibodypedia

BACE2 antibodies
 

PROTEIN VIEW

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BACE2-001
 
BACE2-002
 
BACE2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BACE2-001 ENSP00000332979
ENST00000330333
Q9Y5Z0
Show all »
Show » Show » 518 56.2 Yes 1
BACE2-002 ENSP00000327528
ENST00000347667
Q9Y5Z0
Show all »
Show » Show » 468 50.3 Yes 1
BACE2-003 ENSP00000333854
ENST00000328735
Q9Y5Z0
Show all »
Show » Show » 396 43 Yes 0