NLRP10

GENE INFORMATION

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Gene name

NLRP10 (HGNC Symbol)

Synonyms

CLR11.1, NALP10, NOD8, PAN5, Pynod

Description

NLR family, pyrin domain containing 10 (HGNC Symbol)

Entrez gene summary

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p15.4

Chromosome location (bp)

7980971 - 7986973

Ensembl

ENSG00000182261 (version 73.37)

Entrez gene

338322

UniProt

Q86W26 (UniProt - Evidence at protein level)

neXtProt

NX_Q86W26

Antibodypedia

NLRP10 antibodies
 

PROTEIN VIEW

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NLRP10-001
 
NLRP10-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NLRP10-001 ENSP00000327763
ENST00000328600
Q86W26
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Show » Show » 655 75 No 0
NLRP10-002 ENSP00000436255
ENST00000526590
E9PPY0
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66 7.5 No 0