The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with high, medium, low or not detected (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with antibody staining level high, medium, low or not detected (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients).
By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the literature conformity for the staining pattern revealed by that specific antibody.
Malignancies generally displayed weak to moderate cytoplasmic staining. A few liver-, urothelial- and head & neck cancers were strongly positive. A majority of malignant lymphomas and testicular cancers were negative.
Malignant cells were generally negative. Stromal cells were often distinctly positive. Moderate cytoplasmic immunoreactivity was observed in several cases of malignant melanomas, liver, pancreatic, skin and colorectal cancers.
Partly consistent with extensive gene/protein characterization data
Consistent with extensive gene/protein characterization data
Level of antibody staining/expression
High Medium Low Not detected
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.