LIMK2

GENE INFORMATION

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Gene name

LIMK2

Synonyms

Description

LIM domain kinase 2 (HGNC Symbol)

Entrez gene summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

31608225 - 31676066

Ensembl

ENSG00000182541 (version 73.37)

Entrez gene

3985

UniProt

P53671 (UniProt - Evidence at protein level)

neXtProt

NX_P53671

Antibodypedia

LIMK2 antibodies
 

PROTEIN VIEW

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LIMK2-001
 
LIMK2-002
 
LIMK2-003
 
LIMK2-004
 
LIMK2-005
 
LIMK2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIMK2-001 ENSP00000332687
ENST00000331728
P53671
Show all »
Show » Show » 638 72.2 No 0
LIMK2-002 ENSP00000384602
ENST00000406516
B5MC51
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Show » 629 71.2 No 0
LIMK2-003 ENSP00000339916
ENST00000340552
P53671
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Show » Show » 686 77.9 No 0
LIMK2-004 ENSP00000330470
ENST00000333611
P53671
Show all »
Show » Show » 617 69.9 No 0
LIMK2-005 ENSP00000388422
ENST00000425203
C9JK61
Show all »
Show » 82 9.4 No 0
LIMK2-201 ENSP00000409522
ENST00000444929
E7EUC1
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Show » 392 44.5 No 0