CSF1R

GENE INFORMATION

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Gene name

CSF1R (HGNC Symbol)

Synonyms

C-FMS, CD115, CSFR, FMS

Description

colony stimulating factor 1 receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q32

Chromosome location (bp)

149432854 - 149492935

Ensembl

ENSG00000182578 (version 73.37)

Entrez gene

1436

UniProt

P07333 (UniProt - Evidence at protein level)

neXtProt

NX_P07333

Antibodypedia

CSF1R antibodies
 

PROTEIN VIEW

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CSF1R-001
 
CSF1R-002
 
CSF1R-004
 
CSF1R-007
 
CSF1R-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSF1R-001 ENSP00000286301
ENST00000286301
P07333
Show all »
Show » Show » 972 108 Yes 1
CSF1R-002 ENSP00000422212
ENST00000504875
E9PEK4
Show all »
Show » Show » 671 74.3 Yes 1
CSF1R-004 ENSP00000421174
ENST00000511344
D6RGW1
Show all »
Show » 49 5.8 No 0
CSF1R-007 ENSP00000427545
ENST00000515068
H0YAL5
Show all »
Show » 64 6.6 No 0
CSF1R-201 ENSP00000445282
ENST00000543093
B5A955
Show all »
Show » 306 33.2 Yes 0