LCK

GENE INFORMATION

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Gene name

LCK

Synonyms

Description

lymphocyte-specific protein tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p35.1

Chromosome location (bp)

32716840 - 32751766

Ensembl

ENSG00000182866 (version 73.37)

Entrez gene

3932

UniProt

P06239 (UniProt - Evidence at protein level)

neXtProt

NX_P06239

Antibodypedia

LCK antibodies
 

PROTEIN VIEW

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LCK-001
 
LCK-002
 
LCK-004
 
LCK-006
 
LCK-010
 
LCK-011
 
LCK-012
 
LCK-013
 
LCK-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LCK-001 ENSP00000337825
ENST00000336890
P06239
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Show » Show » 509 58 No 0
LCK-002 ENSP00000431517
ENST00000482949
E9PKQ8
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Show » Show » 200 22.2 No 0
LCK-004 ENSP00000328213
ENST00000333070
P06239
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Show » Show » 539 61.2 No 0
LCK-006 ENSP00000435605
ENST00000495610
E9PJ92
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Show » Show » 319 36 No 0
LCK-010 ENSP00000362658
ENST00000373557
E9PAP0
Show all »
Show » Show » 285 31.6 No 0
LCK-011 ENSP00000436554
ENST00000477031
E9PI33
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Show » 168 17.8 No 0
LCK-012 ENSP00000434525
ENST00000461712
E9PQ10
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Show » Show » 149 16.2 No 0
LCK-013 ENSP00000362663
ENST00000373562
F8W6B9
Show all »
Show » Show » 137 15.3 No 0
LCK-201 ENSP00000362665
ENST00000373564
Q573B4
Show all »
Show » Show » 516 58.3 No 0