EWSR1

GENE INFORMATION

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Gene name

EWSR1 (HGNC Symbol)

Synonyms

EWS

Description

EWS RNA-binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

Chromosome

22 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

29663998 - 29696515

Ensembl

ENSG00000182944 (version 73.37)

Entrez gene

2130

UniProt

Q01844 (UniProt - Evidence at protein level)

neXtProt

NX_Q01844

Antibodypedia

EWSR1 antibodies
 

PROTEIN VIEW

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 « 
 
EWSR1-001
 
EWSR1-002
 
EWSR1-004
 
EWSR1-007
 
EWSR1-008
 
EWSR1-012
 
EWSR1-013
 
EWSR1-014
 
EWSR1-016
 
EWSR1-017
 
EWSR1-018
 
EWSR1-019
 
EWSR1-021
 
EWSR1-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EWSR1-001 ENSP00000381031
ENST00000397938
Q01844
Show all »
Show » Show » 656 68.5 No 0
EWSR1-002 ENSP00000385726
ENST00000406548
Q01844
Show all »
Show » Show » 655 68.4 No 0
EWSR1-004 ENSP00000327456
ENST00000333395
Q01844
Show all »
Show » Show » 354 37.6 No 0
EWSR1-007 ENSP00000330516
ENST00000331029
B0QYK0
Show all »
Show » Show » 618 64.9 No 0
EWSR1-008 ENSP00000331699
ENST00000332035
Q01844
Show all »
Show » Show » 600 62.5 No 0
EWSR1-012 ENSP00000406824
ENST00000436425
B0QYJ3
Show all »
Show » 156 16.3 No 0
EWSR1-013 ENSP00000412670
ENST00000437155
F8WC90
Show all »
Show » 293 31.1 No 0
EWSR1-014 ENSP00000405947
ENST00000447973
B0QYJ4
Show all »
Show » 166 17.3 No 0
EWSR1-016 ENSP00000416171
ENST00000444626
B0QYJ5
Show all »
Show » 77 8.2 No 0
EWSR1-017 ENSP00000395200
ENST00000415761
B0QYJ6
Show all »
Show » 180 19.2 No 0
EWSR1-018 ENSP00000393637
ENST00000455726
B0QYJ7
Show all »
Show » 233 24.6 No 0
EWSR1-019 ENSP00000353204
ENST00000360091
Show » Show » 308 32.1 No 0
EWSR1-021 ENSP00000400142
ENST00000414183
Q01844
Show all »
Show » Show » 661 69 No 0
EWSR1-201 ENSP00000330896
ENST00000332050
C9JGE3
Show all »
Show » Show » 583 61.3 No 0