MTA1

GENE INFORMATION

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Gene name

MTA1

Synonyms

Description

metastasis associated 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Chromosome

14 (Chromosome progress)

Cytoband

q32.33

Chromosome location (bp)

105886159 - 105937066

Ensembl

ENSG00000182979 (version 73.37)

Entrez gene

9112

UniProt

Q13330 (UniProt - Evidence at protein level)

neXtProt

NX_Q13330

Antibodypedia

MTA1 antibodies
 

PROTEIN VIEW

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MTA1-001
 
MTA1-002
 
MTA1-003
 
MTA1-004
 
MTA1-006
 
MTA1-007
 
MTA1-012
 
MTA1-013
 
MTA1-017
 
MTA1-018
 
MTA1-022
 
MTA1-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTA1-001 ENSP00000333633
ENST00000331320
Q13330
Show all »
Show » Show » 715 80.8 No 0
MTA1-002 ENSP00000385702
ENST00000406191
E7ESY4
Show all »
Show » Show » 703 79.4 No 0
MTA1-003 ENSP00000384180
ENST00000405646
Q13330
Show all »
Show » Show » 698 79.2 No 0
MTA1-004 ENSP00000393438
ENST00000438610
Q13330
Show all »
Show » Show » 430 49 No 0
MTA1-006 ENSP00000411493
ENST00000424723
55 5.9 No 0
MTA1-007 ENSP00000394106
ENST00000434050
H0Y4T7
Show all »
Show » Show » 511 57.3 No 0
MTA1-012 ENSP00000395371
ENST00000426567
C9JJM0
Show all »
125 14 Yes 0
MTA1-013 ENSP00000450269
ENST00000494981
142 15.4 No 0
MTA1-017 ENSP00000448146
ENST00000498644
F8VSM3
Show all »
Show » Show » 228 26.1 No 0
MTA1-018 ENSP00000450094
ENST00000551236
Show » 57 6.3 No 0
MTA1-022 ENSP00000446480
ENST00000550551
F8VPC5
Show all »
Show » Show » 46 5.2 No 0
MTA1-201 ENSP00000389425
ENST00000435036
F8W9Y9
Show all »
Show » 255 28.7 No 0