RIPK4

GENERAL INFORMATION

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Gene name

RIPK4

Gene description

Receptor-interacting serine-threonine kinase 4

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (esophagus)
GTEx:Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong cytoplasmic staining was observed in the adrenal gland, pancreas, lymphoid cells and male genitalia. The stomach, follicle cells of the ovary, placental trophoblasts and cells in CNS showed weak to moderate positivity. Remaining normal cells were negative or weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA021158
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (esophagus)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (esophagus)

Organ

Expression



GENE INFORMATION

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Gene name

RIPK4 (HGNC Symbol)

Synonyms

ANKK2, ANKRD3, DIK, PKK, RIP4

Description

Receptor-interacting serine-threonine kinase 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

41739369 - 41767106

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000183421 (version 78.38)

Entrez gene

54101

UniProt

P57078 (UniProt - Evidence at protein level)

neXtProt

NX_P57078

Antibodypedia

RIPK4 antibodies


PROTEIN BROWSER

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ENST00000332512
 
ENST00000352483
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RIPK4-001 ENSP00000332454
ENST00000332512
P57078
Show all »
Show » Show » 784 86.4 No 0
RIPK4-201 ENSP00000330161
ENST00000352483
P57078
Show all »
Show » Show » 832 91.6 No 0