CCR3

GENE INFORMATION

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Gene name

CCR3 (HGNC Symbol)

Synonyms

CC-CKR-3, CD193, CKR3, CMKBR3

Description

chemokine (C-C motif) receptor 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Chromosome

3 (Chromosome progress)

Cytoband

p21.31

Chromosome location (bp)

46205096 - 46308197

Ensembl

ENSG00000183625 (version 73.37)

Entrez gene

1232

UniProt

P51677 (UniProt - Evidence at protein level)

neXtProt

NX_P51677

Antibodypedia

CCR3 antibodies
 

PROTEIN VIEW

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CCR3-001
 
CCR3-002
 
CCR3-003
 
CCR3-004
 
CCR3-007
 
CCR3-201
 
CCR3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR3-001 ENSP00000350003
ENST00000357422
P51677
Show all »
Show » Show » 355 41 No 7
CCR3-002 ENSP00000379271
ENST00000395940
P51677
Show all »
Show » Show » 355 41 No 7
CCR3-003 ENSP00000389336
ENST00000452454
Q8TDP5
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Show » Show » 80 9 No 1
CCR3-004 ENSP00000401822
ENST00000457243
Q8TDP4
Show all »
Show » 21 2.3 No 0
CCR3-007 ENSP00000379273
ENST00000395942
P51677
Show all »
Show » Show » 355 41 No 7
CCR3-201 ENSP00000440097
ENST00000541018
P51677
Show all »
Show » Show » 355 41 No 7
CCR3-202 ENSP00000441600
ENST00000545097
P51677
Show all »
Show » Show » 376 43.5 No 7