NOG

GENE INFORMATION

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Gene name

NOG (HGNC Symbol)

Synonyms

SYM1, SYNS1

Description

noggin (HGNC Symbol)

Entrez gene summary

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q22

Chromosome location (bp)

54671060 - 54672951

Ensembl

ENSG00000183691 (version 73.37)

Entrez gene

9241

UniProt

Q13253 (UniProt - Evidence at protein level)

neXtProt

NX_Q13253

Antibodypedia

NOG antibodies
 

PROTEIN VIEW

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NOG-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOG-001 ENSP00000328181
ENST00000332822
Q13253
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