KCNQ3

GENE INFORMATION

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Gene name

KCNQ3 (HGNC Symbol)

Synonyms

EBN2, Kv7.3

Description

Potassium voltage-gated channel, KQT-like subfamily, member 3 (HGNC Symbol)

Entrez gene summary

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011]

Chromosome

8

Cytoband

q24.22

Chromosome location (bp)

133133108 - 133493200

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184156 (version 75.37)

Entrez gene

3786

UniProt

O43525 (UniProt - Evidence at protein level)

neXtProt

NX_O43525

Antibodypedia

KCNQ3 antibodies
 

PROTEIN VIEW

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KCNQ3-001
 
KCNQ3-002
 
KCNQ3-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNQ3-001 ENSP00000373648
ENST00000388996
O43525
Show all »
Show » Show » 872 96.7 No 5
KCNQ3-002 ENSP00000428790
ENST00000519445
E7ET42
Show all »
Show » Show » 860 95.4 No 5
KCNQ3-004 ENSP00000429799
ENST00000521134
O43525
Show all »
Show » Show » 752 84.8 Yes 4