ADRA2C

GENE INFORMATION

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Gene name

ADRA2C (HGNC Symbol)

Synonyms

ADRA2L2, ADRA2RL2, ADRARL2

Description

adrenoceptor alpha 2C (HGNC Symbol)

Entrez gene summary

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Chromosome

4 (Chromosome progress)

Cytoband

p16.3

Chromosome location (bp)

3768075 - 3770251

Ensembl

ENSG00000184160 (version 73.37)

Entrez gene

152

UniProt

P18825 (UniProt - Evidence at transcript level)

neXtProt

NX_P18825

Antibodypedia

ADRA2C antibodies
 

PROTEIN VIEW

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ADRA2C-001
 
ADRA2C-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRA2C-001 ENSP00000426268
ENST00000509482
D6RGL0
Show all »
Show » Show » 374 38.5 Yes 5
ADRA2C-002 ENSP00000386069
ENST00000330055
P18825
Show all »
Show » Show » 462 49.5 Yes 7