CCR10

GENE INFORMATION

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Gene name

CCR10 (HGNC Symbol)

Synonyms

GPR2

Description

chemokine (C-C motif) receptor 10 (HGNC Symbol)

Entrez gene summary

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

40830907 - 40835935

Ensembl

ENSG00000184451 (version 73.37)

Entrez gene

2826

UniProt

P46092 (UniProt - Evidence at protein level)

neXtProt

NX_P46092

Antibodypedia

CCR10 antibodies
 

PROTEIN VIEW

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CCR10-001
 
CCR10-002
 
CCR10-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR10-001 ENSP00000332504
ENST00000332438
P46092
Show all »
Show » Show » 362 38.4 No 7
CCR10-002 ENSP00000468135
ENST00000591765
K7ER70
Show all »
Show » Show » 140 15.3 No 2
CCR10-003 ENSP00000467331
ENST00000591568
K7EPC9
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Show » Show » 83 8.8 No 1