TXNRD2

GENE INFORMATION

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Gene name

TXNRD2 (HGNC Symbol)

Synonyms

TR, TR3, TRXR2

Description

thioredoxin reductase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]

Chromosome

22 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

19863040 - 19929341

Ensembl

ENSG00000184470 (version 73.37)

Entrez gene

10587

UniProt

Q9NNW7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NNW7

Antibodypedia

TXNRD2 antibodies
 

PROTEIN VIEW

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TXNRD2-003
 
TXNRD2-004
 
TXNRD2-006
 
TXNRD2-012
 
TXNRD2-201
 
TXNRD2-202
 
TXNRD2-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TXNRD2-003 ENSP00000383365
ENST00000400521
Q9NNW7
Show all »
Show » Show » 524 56.5 No 0
TXNRD2-004 ENSP00000383362
ENST00000400518
F5H1L4
Show all »
Show » Show » 494 53.6 No 0
TXNRD2-006 ENSP00000383369
ENST00000400525
Show » Show » 501 54.3 No 0
TXNRD2-012 ENSP00000383363
ENST00000400519
F5H2V0
Show all »
Show » Show » 523 56.4 No 0
TXNRD2-201 ENSP00000334451
ENST00000334363
E7EWK1
Show all »
Show » Show » 338 36.3 No 0
TXNRD2-202 ENSP00000439314
ENST00000535882
F5H2V0
Show all »
Show » Show » 521 56.2 No 0
TXNRD2-203 ENSP00000439570
ENST00000542719
F5H1L4
Show all »
Show » Show » 492 53.4 No 0